Insight Into Molecular Determinants of T3 vs T4 Recognition From Mutations in Thyroid Hormone Receptor α and β

CONTEXT: The two major forms of circulating thyroid hormones (THs) are T3 and T4. T3 is regarded as the biologically active hormone because it binds to TH receptors (TRs) with greater affinity than T4. However, it is currently unclear what structural mechanisms underlie this difference in affinity....

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Bibliografiset tiedot
Julkaisussa:J Clin Endocrinol Metab
Päätekijät: Wejaphikul, Karn, Groeneweg, Stefan, Hilhorst-Hofstee, Yvonne, Chatterjee, V Krishna, Peeters, Robin P, Meima, Marcel E, Visser, W Edward
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Endocrine Society 2019
Aiheet:
Clinical Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599431/
https://ncbi.nlm.nih.gov/pubmed/30817817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2018-02794
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