Insight Into Molecular Determinants of T3 vs T4 Recognition From Mutations in Thyroid Hormone Receptor α and β

CONTEXT: The two major forms of circulating thyroid hormones (THs) are T3 and T4. T3 is regarded as the biologically active hormone because it binds to TH receptors (TRs) with greater affinity than T4. However, it is currently unclear what structural mechanisms underlie this difference in affinity....

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Bibliografiske detaljer
Udgivet i:J Clin Endocrinol Metab
Main Authors: Wejaphikul, Karn, Groeneweg, Stefan, Hilhorst-Hofstee, Yvonne, Chatterjee, V Krishna, Peeters, Robin P, Meima, Marcel E, Visser, W Edward
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2019
Fag:
Clinical Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599431/
https://ncbi.nlm.nih.gov/pubmed/30817817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2018-02794
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