Insight Into Molecular Determinants of T3 vs T4 Recognition From Mutations in Thyroid Hormone Receptor α and β

CONTEXT: The two major forms of circulating thyroid hormones (THs) are T3 and T4. T3 is regarded as the biologically active hormone because it binds to TH receptors (TRs) with greater affinity than T4. However, it is currently unclear what structural mechanisms underlie this difference in affinity....

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Vydáno v:J Clin Endocrinol Metab
Hlavní autoři: Wejaphikul, Karn, Groeneweg, Stefan, Hilhorst-Hofstee, Yvonne, Chatterjee, V Krishna, Peeters, Robin P, Meima, Marcel E, Visser, W Edward
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2019
Témata:
Clinical Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599431/
https://ncbi.nlm.nih.gov/pubmed/30817817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2018-02794
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