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Insight Into Molecular Determinants of T3 vs T4 Recognition From Mutations in Thyroid Hormone Receptor α and β

CONTEXT: The two major forms of circulating thyroid hormones (THs) are T3 and T4. T3 is regarded as the biologically active hormone because it binds to TH receptors (TRs) with greater affinity than T4. However, it is currently unclear what structural mechanisms underlie this difference in affinity....

詳細記述

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書誌詳細
出版年:J Clin Endocrinol Metab
主要な著者: Wejaphikul, Karn, Groeneweg, Stefan, Hilhorst-Hofstee, Yvonne, Chatterjee, V Krishna, Peeters, Robin P, Meima, Marcel E, Visser, W Edward
フォーマット: Artigo
言語:Inglês
出版事項: Endocrine Society 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599431/
https://ncbi.nlm.nih.gov/pubmed/30817817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2018-02794
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