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How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers
Point mutations in the coding sequence for solute carrier 6 (SLC6) family members result in clinically relevant disorders, which are often accounted for by a loss-of-function phenotype. In many instances, the mutated transporter is not delivered to the cell surface because it is retained in the endo...
Guardat en:
| Publicat a: | Biochem Soc Trans |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Portland Press Ltd.
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6599159/ https://ncbi.nlm.nih.gov/pubmed/31064865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20180512 |
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