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How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers
Point mutations in the coding sequence for solute carrier 6 (SLC6) family members result in clinically relevant disorders, which are often accounted for by a loss-of-function phenotype. In many instances, the mutated transporter is not delivered to the cell surface because it is retained in the endo...
Zapisane w:
| Wydane w: | Biochem Soc Trans |
|---|---|
| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Portland Press Ltd.
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6599159/ https://ncbi.nlm.nih.gov/pubmed/31064865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20180512 |
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