Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute

Hemoglobin (Hb)-based oxygen carriers (HBOC) are modified extracellular proteins, designed to replace or augment the oxygen-carrying capacity of erythrocytes. However, clinical results have generally been disappointing due to adverse side effects, in part linked to the intrinsic oxidative toxicity o...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Free Radic Biol Med
Asıl Yazarlar: Cooper, Chris E., Silkstone, Gary G.A., Simons, Michelle, Rajagopal, Badri, Syrett, Natalie, Shaik, Thoufieq, Gretton, Svetlana, Welbourn, Elizabeth, Bülow, Leif, Eriksson, Nélida Leiva, Ronda, Luca, Mozzarelli, Andrea, Eke, Andras, Mathe, Domokos, Reeder, Brandon J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier Science 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597946/
https://ncbi.nlm.nih.gov/pubmed/30594736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.12.030
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller