Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers

Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been engineered to replace or augment the oxygen carrying capacity of erythrocytes. However, clinical results have generally been disappointing, in part due to the intrinsic oxidative toxicity of Hb. The most common HBOC starting material is adult h...

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Vydáno v:Biosci Rep
Hlavní autoři: Simons, Michelle, Gretton, Svetlana, Silkstone, Gary G.A., Rajagopal, Badri S., Allen-Baume, Victoria, Syrett, Natalie, Shaik, Thoufieq, Leiva-Eriksson, Nelida, Ronda, Luca, Mozzarelli, Andrea, Strader, Michael B., Alayash, Abdu I., Reeder, Brandon J., Cooper, Chris E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028758/
https://ncbi.nlm.nih.gov/pubmed/29802155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180370
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