Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers

Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been engineered to replace or augment the oxygen carrying capacity of erythrocytes. However, clinical results have generally been disappointing, in part due to the intrinsic oxidative toxicity of Hb. The most common HBOC starting material is adult h...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Biosci Rep
Päätekijät: Simons, Michelle, Gretton, Svetlana, Silkstone, Gary G.A., Rajagopal, Badri S., Allen-Baume, Victoria, Syrett, Natalie, Shaik, Thoufieq, Leiva-Eriksson, Nelida, Ronda, Luca, Mozzarelli, Andrea, Strader, Michael B., Alayash, Abdu I., Reeder, Brandon J., Cooper, Chris E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Portland Press Ltd. 2018
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028758/
https://ncbi.nlm.nih.gov/pubmed/29802155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180370
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