Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers

Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been engineered to replace or augment the oxygen carrying capacity of erythrocytes. However, clinical results have generally been disappointing, in part due to the intrinsic oxidative toxicity of Hb. The most common HBOC starting material is adult h...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Simons, Michelle, Gretton, Svetlana, Silkstone, Gary G.A., Rajagopal, Badri S., Allen-Baume, Victoria, Syrett, Natalie, Shaik, Thoufieq, Leiva-Eriksson, Nelida, Ronda, Luca, Mozzarelli, Andrea, Strader, Michael B., Alayash, Abdu I., Reeder, Brandon J., Cooper, Chris E.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028758/
https://ncbi.nlm.nih.gov/pubmed/29802155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180370
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