Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers

Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been engineered to replace or augment the oxygen carrying capacity of erythrocytes. However, clinical results have generally been disappointing, in part due to the intrinsic oxidative toxicity of Hb. The most common HBOC starting material is adult h...

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Dades bibliogràfiques
Publicat a:Biosci Rep
Autors principals: Simons, Michelle, Gretton, Svetlana, Silkstone, Gary G.A., Rajagopal, Badri S., Allen-Baume, Victoria, Syrett, Natalie, Shaik, Thoufieq, Leiva-Eriksson, Nelida, Ronda, Luca, Mozzarelli, Andrea, Strader, Michael B., Alayash, Abdu I., Reeder, Brandon J., Cooper, Chris E.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028758/
https://ncbi.nlm.nih.gov/pubmed/29802155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180370
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