Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design

Hemoglobin (Hb)-based oxygen carriers (HBOC) have been engineered to replace or augment the oxygen-carrying capacity of erythrocytes. However, clinical results have generally been disappointing due to adverse side effects linked to intrinsic heme-mediated oxidative toxicity and nitric oxide (NO) sca...

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Veröffentlicht in:Biochem J
Hauptverfasser: Silkstone, Gary G.A., Silkstone, Rebecca S., Wilson, Michael T., Simons, Michelle, Bülow, Leif, Kallberg, Kristian, Ratanasopa, Khuanpiroon, Ronda, Luca, Mozzarelli, Andrea, Reeder, Brandon J., Cooper, Chris E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095908/
https://ncbi.nlm.nih.gov/pubmed/27470146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160243
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