Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine β145

Aim: Hemoglobin (Hb) becomes toxic when released from the erythrocyte. The acute phase protein haptoglobin (Hp) binds avidly to Hb and decreases oxidative damage to Hb itself and to the surrounding proteins and lipids. However, the molecular mechanism underpinning Hp protection is to date unclear. T...

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Detalhes bibliográficos
Main Authors: Cooper, Chris E., Schaer, Dominik J., Buehler, Paul W., Wilson, Michael T., Reeder, Brandon J., Silkstone, Gary, Svistunenko, Dimitri A., Bulow, Leif, Alayash, Abdu I.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Forum Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638561/
https://ncbi.nlm.nih.gov/pubmed/22702311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.4547
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