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Ferryl haem protonation gates peroxidatic reactivity in globins

Ferryl (Fe(IV)=O) species are involved in key enzymatic processes with direct biomedical relevance; among others, the uncontrolled reactivities of ferryl Mb (myoglobin) and Hb (haemoglobin) have been reported to be central to the pathology of rhabdomyolysis and subarachnoid haemorrhage. Rapid-scan s...

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Autors principals: Silaghi-Dumitrescu, Radu, Reeder, Brandon J., Nicholls, Peter, Cooper, Chris E., Wilson, Michael T.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876371/
https://ncbi.nlm.nih.gov/pubmed/17214588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061421
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