Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute

Hemoglobin (Hb)-based oxygen carriers (HBOC) are modified extracellular proteins, designed to replace or augment the oxygen-carrying capacity of erythrocytes. However, clinical results have generally been disappointing due to adverse side effects, in part linked to the intrinsic oxidative toxicity o...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Cooper, Chris E., Silkstone, Gary G.A., Simons, Michelle, Rajagopal, Badri, Syrett, Natalie, Shaik, Thoufieq, Gretton, Svetlana, Welbourn, Elizabeth, Bülow, Leif, Eriksson, Nélida Leiva, Ronda, Luca, Mozzarelli, Andrea, Eke, Andras, Mathe, Domokos, Reeder, Brandon J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597946/
https://ncbi.nlm.nih.gov/pubmed/30594736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.12.030
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