Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis

The Myc gene is a universal oncogene that promotes aggressive cancer, but its role in metastasis has remained elusive. Here, we show that Myc transcriptionally controls a gene network of subcellular mitochondrial trafficking that includes the atypical mitochondrial GTPases RHOT1 and RHOT2, the adapt...

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Publicat a:Mol Cell Biol
Autors principals: Agarwal, Ekta, Altman, Brian J., Ho Seo, Jae, Bertolini, Irene, Ghosh, Jagadish C., Kaur, Amanpreet, Kossenkov, Andrew V., Languino, Lucia R., Gabrilovich, Dmitry I., Speicher, David W., Dang, Chi V., Altieri, Dario C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597883/
https://ncbi.nlm.nih.gov/pubmed/31061095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00109-19
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