Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease

Oxidative stress is elevated in the recipients of allogeneic hematopoietic cell transplantation (allo-HCT) and likely contributes to the development of graft-versus-host disease (GVHD). GVHD is characterized by activation, expansion, cytokine production, and migration of alloreactive donor T cells,...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Sofi, M. Hanief, Wu, Yongxia, Schutt, Steven D., Dai, Min, Daenthanasanmak, Anusara, Heinrichs Voss, Jessica, Nguyen, Hung, Bastian, David, Iamsawat, Supinya, Selvam, Shanmugam Panneer, Liu, Chen, Maulik, Nilanjana, Ogretmen, Besim, Jin, Junfei, Mehrotra, Shikhar, Yu, Xue-Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597211/
https://ncbi.nlm.nih.gov/pubmed/31045571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122899
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