Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice

Graft-versus-host disease (GVHD) remains one of the major complications after allogeneic bone marrow transplantation (allo-BMT). Sirtuin-1 (Sirt-1) plays a crucial role in various biological processes including cellular senescence, metabolism, and inflammatory responses. Sirt-1 deacetylation regulat...

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Vydáno v:Blood
Hlavní autoři: Daenthanasanmak, Anusara, Iamsawat, Supinya, Chakraborty, Paramita, Nguyen, Hung D., Bastian, David, Liu, Chen, Mehrotra, Shikhar, Yu, Xue-Zhong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337874/
https://ncbi.nlm.nih.gov/pubmed/30514750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-07-863233
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