Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells

Adoptive transfer of tumor epitope–reactive T cells has emerged as a promising strategy to control tumor growth. However, chronically-stimulated T cells expanded for adoptive cell transfer are susceptible to cell death in an oxidative tumor microenvironment. Because oxidation of cell-surface thiols...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chakraborty, Paramita, Chatterjee, Shilpak, Kesarwani, Pravin, Thyagarajan, Krishnamurthy, Iamsawat, Supinya, Dalheim, Annika, Nguyen, Hung, Selvam, Shanmugam P., Nasarre, Patrick, Scurti, Gina, Hardiman, Gary, Maulik, Nilanjana, Ball, Lauren, Gangaraju, Vamsi, Rubinstein, Mark P., Klauber-DeMore, Nancy, Hill, Elizabeth G., Ogretmen, Besim, Yu, Xue-Zhong, Nishimura, Michael I., Mehrotra, Shikhar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556575/
https://ncbi.nlm.nih.gov/pubmed/30971427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006753
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