APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission

The amyloid precursor protein (APP), a key player in Alzheimer's disease, belongs to the family of synaptic adhesion molecules (SAMs) due to its impact on synapse formation and synaptic plasticity. These functions are mediated by both the secreted APP ectodomain that acts as a neurotrophic fact...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Schilling, Sandra, Mehr, Annika, Ludewig, Susann, Stephan, Jonathan, Zimmermann, Marius, August, Alexander, Strecker, Paul, Korte, Martin, Koo, Edward H., Müller, Ulrike C., Kins, Stefan, Eggert, Simone
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2017
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596463/
https://ncbi.nlm.nih.gov/pubmed/28450540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1875-16.2017
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