APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission

The amyloid precursor protein (APP), a key player in Alzheimer's disease, belongs to the family of synaptic adhesion molecules (SAMs) due to its impact on synapse formation and synaptic plasticity. These functions are mediated by both the secreted APP ectodomain that acts as a neurotrophic fact...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Schilling, Sandra, Mehr, Annika, Ludewig, Susann, Stephan, Jonathan, Zimmermann, Marius, August, Alexander, Strecker, Paul, Korte, Martin, Koo, Edward H., Müller, Ulrike C., Kins, Stefan, Eggert, Simone
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596463/
https://ncbi.nlm.nih.gov/pubmed/28450540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1875-16.2017
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