Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2

CRISPR-Cas adaptive immune systems function to protect bacteria from invasion by foreign genetic elements. The CRISPR-Cas9 system has been widely adopted as a powerful genome-editing tool, and phage-encoded inhibitors, known as anti-CRISPRs, offer a means of regulating its activity. Here, we report...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Thavalingam, Annoj, Cheng, Zhi, Garcia, Bianca, Huang, Xue, Shah, Megha, Sun, Wei, Wang, Min, Harrington, Lucas, Hwang, Sungwon, Hidalgo-Reyes, Yurima, Sontheimer, Erik J., Doudna, Jennifer, Davidson, Alan R., Moraes, Trevor F., Wang, Yanli, Maxwell, Karen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594998/
https://ncbi.nlm.nih.gov/pubmed/31243272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10577-3
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