Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Elimination of senescent cells (SnC) is anti-atherogenic, but the specific contribution of senescent vascular endothelial cells (EC) is unknown. We inactivated angiopoietin like-2 (angptl2), a marker of SnEC and a pro-atherogenic cytokine in LDLr(-/-), hApoB(100)(+/+) atherosclerotic (ATX) mice. Thr...

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Bibliografiske detaljer
Udgivet i:Aging (Albany NY)
Main Authors: Caland, Laurie, Labbé, Pauline, Mamarbachi, Maya, Villeneuve, Louis, Ferbeyre, Gerardo, Noly, Pierre-Emmanuel, Carrier, Michel, Thorin-Trescases, Nathalie, Thorin, Éric
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594793/
https://ncbi.nlm.nih.gov/pubmed/31186381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102020
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