Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Elimination of senescent cells (SnC) is anti-atherogenic, but the specific contribution of senescent vascular endothelial cells (EC) is unknown. We inactivated angiopoietin like-2 (angptl2), a marker of SnEC and a pro-atherogenic cytokine in LDLr(-/-), hApoB(100)(+/+) atherosclerotic (ATX) mice. Thr...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Aging (Albany NY)
Hlavní autoři: Caland, Laurie, Labbé, Pauline, Mamarbachi, Maya, Villeneuve, Louis, Ferbeyre, Gerardo, Noly, Pierre-Emmanuel, Carrier, Michel, Thorin-Trescases, Nathalie, Thorin, Éric
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594793/
https://ncbi.nlm.nih.gov/pubmed/31186381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102020
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky