Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Elimination of senescent cells (SnC) is anti-atherogenic, but the specific contribution of senescent vascular endothelial cells (EC) is unknown. We inactivated angiopoietin like-2 (angptl2), a marker of SnEC and a pro-atherogenic cytokine in LDLr(-/-), hApoB(100)(+/+) atherosclerotic (ATX) mice. Thr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Caland, Laurie, Labbé, Pauline, Mamarbachi, Maya, Villeneuve, Louis, Ferbeyre, Gerardo, Noly, Pierre-Emmanuel, Carrier, Michel, Thorin-Trescases, Nathalie, Thorin, Éric
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594793/
https://ncbi.nlm.nih.gov/pubmed/31186381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102020
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados