Endogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells

INTRODUCTION: With aging, oxidative stress accelerates vascular endothelial cell (EC) telomere shortening-induced senescence, and may promote atherosclerosis in humans. Our aim was to investigate whether an antioxidant treatment combined with telomerase (hTERT) over-expression would prevent senescen...

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Auteurs principaux: Voghel, Guillaume, Thorin-Trescases, Nathalie, Mamarbachi, Aida M., Villeneuve, Louis, Mallette, Frédérick A., Ferbeyre, Gerardo, Farhat, Nada, Perrault, Louis P., Carrier, Michel, Thorin, Eric
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700881/
https://ncbi.nlm.nih.gov/pubmed/20399802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2010.04.004
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