Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

In amyotrophic lateral sclerosis (ALS) spinal motor neurons (SpMN) progressively degenerate while a subset of cranial motor neurons (CrMN) are spared until late stages of the disease. Using a rapid and efficient protocol to differentiate mouse embryonic stem cells (ESC) to SpMNs and CrMNs, we now re...

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發表在:eLife
Main Authors: An, Disi, Fujiki, Ryosuke, Iannitelli, Dylan E, Smerdon, John W, Maity, Shuvadeep, Rose, Matthew F, Gelber, Alon, Wanaselja, Elizabeth K, Yagudayeva, Ilona, Lee, Joun Y, Vogel, Christine, Wichterle, Hynek, Engle, Elizabeth C, Mazzoni, Esteban Orlando
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2019
主題:
Neuroscience
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594754/
https://ncbi.nlm.nih.gov/pubmed/31157617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44423
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