Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

In amyotrophic lateral sclerosis (ALS) spinal motor neurons (SpMN) progressively degenerate while a subset of cranial motor neurons (CrMN) are spared until late stages of the disease. Using a rapid and efficient protocol to differentiate mouse embryonic stem cells (ESC) to SpMNs and CrMNs, we now re...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: An, Disi, Fujiki, Ryosuke, Iannitelli, Dylan E, Smerdon, John W, Maity, Shuvadeep, Rose, Matthew F, Gelber, Alon, Wanaselja, Elizabeth K, Yagudayeva, Ilona, Lee, Joun Y, Vogel, Christine, Wichterle, Hynek, Engle, Elizabeth C, Mazzoni, Esteban Orlando
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594754/
https://ncbi.nlm.nih.gov/pubmed/31157617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44423
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