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Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores

Since publication of the crystal structure of protein kinase (PK)A three decades ago, a structural portrait of the conserved kinase core has been drawn. The next challenge is to elucidate structures of full-length kinases and to address the intrinsically disordered regions (IDRs) that typically flan...

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Bibliografiske detaljer
Udgivet i:Trends Biochem Sci
Main Authors: Gógl, Gergő, Kornev, Alexandr P., Reményi, Attila, Taylor, Susan S.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592696/
https://ncbi.nlm.nih.gov/pubmed/30611608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2018.12.002
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