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Protein–peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase

Linear motifs normally bind with only medium binding affinity (K (d) of ∼0.1–10 µM) to shallow protein-interaction surfaces on their binding partners. The crystallization of proteins in complex with linear motif-containing peptides is often challenging because the energy gained upon crystal packing...

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Détails bibliographiques
Auteurs principaux: Gógl, Gergő, Törő, Imre, Reményi, Attila
Format: Artigo
Langue:Inglês
Publié: International Union of Crystallography 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605046/
https://ncbi.nlm.nih.gov/pubmed/23519423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912051062
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