Identification of a Small Molecule Inhibitor of the Aminoglycoside 6’-NAcetyltransferase Type Ib [AAC(6’)-Ib] Using Mixture-Based Combinatorial Libraries

The aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6’)-Ib] is the most widely distributed enzyme among AAC(6’)-I-producing Gram-negative pathogens and confers resistance to clinically relevant aminoglycosides including amikacin. This enzyme is therefore ideal to target with enzymatic inhibitors...

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Publicado en:Int J Antimicrob Agents
Autores principales: Tran, Tung, Chiem, Kevin, Jani, Saumya, Arivett, Brock A., Lin, David L., Lad, Rupali, Jimenez, Verónica, Farone, Mary B., Debevec, Ginamarie, Santos, Radleigh, Giulianotti, Marc, Pinilla, Clemencia, Tolmasky, Marcelo E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592615/
https://ncbi.nlm.nih.gov/pubmed/29410367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2018.01.019
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