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NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells
The mechanistic basis of gliogenesis, which occurs late in human development, is poorly understood. Here we identify nuclear factor IA (NFIA) as a molecular switch for inducing human glial competency. Transient expression of NFIA is sufficient to trigger glial competency of human pluripotent stem ce...
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| Publicado no: | Nat Biotechnol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6591152/ https://ncbi.nlm.nih.gov/pubmed/30804533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0035-0 |
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