Functional connectivity under optogenetic control allows modeling of human neuromuscular disease

Capturing the full potential of human pluripotent stem cell (PSC)-derived neurons in disease modeling and regenerative medicine requires analysis in complex functional systems. Here we establish optogenetic control in human PSC-derived spinal motorneurons and show that co-culture of these cells with...

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Bibliographic Details
Published in:Cell Stem Cell
Main Authors: Steinbeck, Julius A., Jaiswal, Manoj K., Calder, Elizabeth L, Kishinevsky, Sarah, Weishaupt, Andreas, Toyka, Klaus V., Goldstein, Peter A., Studer, Lorenz
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707991/
https://ncbi.nlm.nih.gov/pubmed/26549107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.10.002
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