NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells

The mechanistic basis of gliogenesis, which occurs late in human development, is poorly understood. Here we identify nuclear factor IA (NFIA) as a molecular switch for inducing human glial competency. Transient expression of NFIA is sufficient to trigger glial competency of human pluripotent stem ce...

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Publicado en:Nat Biotechnol
Autores principales: Tchieu, Jason, Calder, Elizabeth L., Guttikonda, Sudha R., Gutzwiller, Eveline M., Aromolaran, Kelly A., Steinbeck, Julius A., Goldstein, Peter A., Studer, Lorenz
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591152/
https://ncbi.nlm.nih.gov/pubmed/30804533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0035-0
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