Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation

The derivation of somatic motoneurons (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) and retinoic acid (RA) is one of the best defined, directed differentiation strategies to specify fate in pluripotent lineages. In mouse ESCs, MN yield is particularly high after RA + SHH treatmen...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Calder, Elizabeth L., Tchieu, Jason, Steinbeck, Julius A., Tu, Edmund, Keros, Sotirios, Ying, Shui-Wang, Jaiswal, Manoj K., Cornacchia, Daniela, Goldstein, Peter A., Tabar, Viviane, Studer, Lorenz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540792/
https://ncbi.nlm.nih.gov/pubmed/26290227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3046-14.2015
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