Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation

The derivation of somatic motoneurons (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) and retinoic acid (RA) is one of the best defined, directed differentiation strategies to specify fate in pluripotent lineages. In mouse ESCs, MN yield is particularly high after RA + SHH treatmen...

Full description

Saved in:
Bibliographic Details
Published in:J Neurosci
Main Authors: Calder, Elizabeth L., Tchieu, Jason, Steinbeck, Julius A., Tu, Edmund, Keros, Sotirios, Ying, Shui-Wang, Jaiswal, Manoj K., Cornacchia, Daniela, Goldstein, Peter A., Tabar, Viviane, Studer, Lorenz
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2015
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540792/
https://ncbi.nlm.nih.gov/pubmed/26290227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3046-14.2015
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items