Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation

The derivation of somatic motoneurons (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) and retinoic acid (RA) is one of the best defined, directed differentiation strategies to specify fate in pluripotent lineages. In mouse ESCs, MN yield is particularly high after RA + SHH treatmen...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Calder, Elizabeth L., Tchieu, Jason, Steinbeck, Julius A., Tu, Edmund, Keros, Sotirios, Ying, Shui-Wang, Jaiswal, Manoj K., Cornacchia, Daniela, Goldstein, Peter A., Tabar, Viviane, Studer, Lorenz
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540792/
https://ncbi.nlm.nih.gov/pubmed/26290227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3046-14.2015
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