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Design, synthesis and evaluation of [(111)In]-labeled, DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors

INTRODUCTION: Peripheral mu (μ) opioid receptors are implicated in pain, bowel dysfunction and the progression of certain cancers. In an effort to identify radioligands well suited for imaging these peripheral sites, we have prepared and evaluated four hydrophilic [(111)In]-labeled, DOTA (1,4,7,10-t...

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Dettagli Bibliografici
Pubblicato in:Nucl Med Biol
Autori principali: Lever, John R., Fergason-Cantrell, Emily A., Carmack, Terry L., Watkinson, Lisa D., Gallazzi, Fabio
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591026/
https://ncbi.nlm.nih.gov/pubmed/30933866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2019.02.001
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