DEVELOPMENT AND IN VITRO CHARACTERIZATION OF A NOVEL BIFUNCTIONAL MU-AGONIST/DELTA-ANTAGONIST OPIOID TETRAPEPTIDE

The development of tolerance to and dependence on opioid analgesics greatly reduces their long-term usefulness. Previous studies have demonstrated that co-administration of a mu opioid receptor (MOR) agonist and delta opioid receptor (DOR) antagonist can decrease MOR agonist induced tolerance and de...

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Hlavní autoři: Purington, Lauren C., Sobczyk-Kojiro, Katarzyna, Pogozheva, Irina D., Traynor, John R., Mosberg, Henry I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241856/
https://ncbi.nlm.nih.gov/pubmed/21958158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200263q
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