Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid

Enterovirus A71 (EV-A71) is a non-polio neurotropic enterovirus with pandemic potential. There are no antiviral agents approved to prevent or treat EV-A71 infections. We here report on the molecular mechanism by which a novel class of tryptophan dendrimers inhibits (at low nanomolar to high picomola...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Sun, Liang, Lee, Hyunwook, Thibaut, Hendrik Jan, Lanko, Kristina, Rivero-Buceta, Eva, Bator, Carol, Martinez-Gualda, Belen, Dallmeier, Kai, Delang, Leen, Leyssen, Pieter, Gago, Federico, San-Félix, Ana, Hafenstein, Susan, Mirabelli, Carmen, Neyts, Johan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590834/
https://ncbi.nlm.nih.gov/pubmed/31071193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007760
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