Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71

Tryptophan dendrimers that inhibit HIV replication by binding to the HIV envelope glycoproteins gp120 and gp41 have unexpectedly also proven to be potent, specific, and selective inhibitors of the replication of the unrelated enterovirus A71. Dendrimer 12, a consensus compound that was synthesized o...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Rivero-Buceta, Eva, Sun, Liang, Martínez-Gualda, Belén, Doyagüez, Elisa G., Donckers, Kim, Quesada, Ernesto, Camarasa, María-José, Delang, Leen, San-Félix, Ana, Neyts, Johan, Leyssen, Pieter
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958208/
https://ncbi.nlm.nih.gov/pubmed/27246775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00626-16
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