Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71

Tryptophan dendrimers that inhibit HIV replication by binding to the HIV envelope glycoproteins gp120 and gp41 have unexpectedly also proven to be potent, specific, and selective inhibitors of the replication of the unrelated enterovirus A71. Dendrimer 12, a consensus compound that was synthesized o...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Rivero-Buceta, Eva, Sun, Liang, Martínez-Gualda, Belén, Doyagüez, Elisa G., Donckers, Kim, Quesada, Ernesto, Camarasa, María-José, Delang, Leen, San-Félix, Ana, Neyts, Johan, Leyssen, Pieter
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958208/
https://ncbi.nlm.nih.gov/pubmed/27246775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00626-16
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