A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are “capsid binders” that fit in a hydrophobic pocket of the viral capsid. Employing a new class of entero-/rhinovirus inhibitors and by means of cryo–electron microscopy (E...

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Detaylı Bibliyografya
Yayımlandı:PLoS Biol
Asıl Yazarlar: Abdelnabi, Rana, Geraets, James A., Ma, Yipeng, Mirabelli, Carmen, Flatt, Justin W., Domanska, Aušra, Delang, Leen, Jochmans, Dirk, Kumar, Timiri Ajay, Jayaprakash, Venkatesan, Sinha, Barij Nayan, Leyssen, Pieter, Butcher, Sarah J., Neyts, Johan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559632/
https://ncbi.nlm.nih.gov/pubmed/31185007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000281
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