A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are “capsid binders” that fit in a hydrophobic pocket of the viral capsid. Employing a new class of entero-/rhinovirus inhibitors and by means of cryo–electron microscopy (E...

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Publicado en:PLoS Biol
Autores principales: Abdelnabi, Rana, Geraets, James A., Ma, Yipeng, Mirabelli, Carmen, Flatt, Justin W., Domanska, Aušra, Delang, Leen, Jochmans, Dirk, Kumar, Timiri Ajay, Jayaprakash, Venkatesan, Sinha, Barij Nayan, Leyssen, Pieter, Butcher, Sarah J., Neyts, Johan
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559632/
https://ncbi.nlm.nih.gov/pubmed/31185007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000281
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