A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are “capsid binders” that fit in a hydrophobic pocket of the viral capsid. Employing a new class of entero-/rhinovirus inhibitors and by means of cryo–electron microscopy (E...

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Bibliografske podrobnosti
izdano v:PLoS Biol
Main Authors: Abdelnabi, Rana, Geraets, James A., Ma, Yipeng, Mirabelli, Carmen, Flatt, Justin W., Domanska, Aušra, Delang, Leen, Jochmans, Dirk, Kumar, Timiri Ajay, Jayaprakash, Venkatesan, Sinha, Barij Nayan, Leyssen, Pieter, Butcher, Sarah J., Neyts, Johan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559632/
https://ncbi.nlm.nih.gov/pubmed/31185007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000281
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