A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are “capsid binders” that fit in a hydrophobic pocket of the viral capsid. Employing a new class of entero-/rhinovirus inhibitors and by means of cryo–electron microscopy (E...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS Biol
Autori principali: Abdelnabi, Rana, Geraets, James A., Ma, Yipeng, Mirabelli, Carmen, Flatt, Justin W., Domanska, Aušra, Delang, Leen, Jochmans, Dirk, Kumar, Timiri Ajay, Jayaprakash, Venkatesan, Sinha, Barij Nayan, Leyssen, Pieter, Butcher, Sarah J., Neyts, Johan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559632/
https://ncbi.nlm.nih.gov/pubmed/31185007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000281
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi