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Reactive cysteine residues in the oxidative dimerization and Cu(2+) induced aggregation of human γD-crystallin: Implications for age-related cataract
Cysteine (Cys) residues are major causes of crystallin disulfide formation and aggregation in aging and cataractous human lenses. We recently found that disulfide linkages are highly and partly conserved in β-and γ-crystallins, respectively, in human age-related nuclear cataract and glutathione depl...
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| Publicado en: | Biochim Biophys Acta Mol Basis Dis |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6590075/ https://ncbi.nlm.nih.gov/pubmed/30251679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2018.08.021 |
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