Evidence of Highly Conserved β-Crystallin Disulfidome that Can be Mimicked by In Vitro Oxidation in Age-related Human Cataract and Glutathione Depleted Mouse Lens

Low glutathione levels are associated with crystallin oxidation in age-related nuclear cataract. To understand the role of cysteine residue oxidation, we used the novel approach of comparing human cataracts with glutathione-depleted LEGSKO mouse lenses for intra- versus intermolecular disulfide cros...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Fan, Xingjun, Zhou, Sheng, Wang, Benlian, Hom, Grant, Guo, Minfei, Li, Binbin, Yang, Jing, Vaysburg, Dennis, Monnier, Vincent M
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762625/
https://ncbi.nlm.nih.gov/pubmed/26453637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.050948
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