TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion

T cells expressing chimeric antigen receptors (CAR T cells) have shown impressive therapeutic efficacy against leukemias and lymphomas. However, they have not been as effective against solid tumors because they become hyporesponsive (“exhausted” or “dysfunctional”) within the tumor microenvironment,...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Seo, Hyungseok, Chen, Joyce, González-Avalos, Edahí, Samaniego-Castruita, Daniela, Das, Arundhoti, Wang, Yueqiang H., López-Moyado, Isaac F., Georges, Romain O., Zhang, Wade, Onodera, Atsushi, Wu, Cheng-Jang, Lu, Li-Fan, Hogan, Patrick G., Bhandoola, Avinash, Rao, Anjana
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589758/
https://ncbi.nlm.nih.gov/pubmed/31152140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905675116
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