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BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells
The transcription factors NFAT and AP-1 (Fos-Jun) cooperate to promote the effector functions of T cells, but NFAT in the absence of AP-1 imposes a negative feedback program of T cell hyporesponsiveness (“exhaustion”). Here we show that BATF and IRF4 cooperate to counter T cell exhaustion in mouse t...
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| Publicado no: | Nat Immunol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8319109/ https://ncbi.nlm.nih.gov/pubmed/34282330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-00964-8 |
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