TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion

T cells expressing chimeric antigen receptors (CAR T cells) have shown impressive therapeutic efficacy against leukemias and lymphomas. However, they have not been as effective against solid tumors because they become hyporesponsive (“exhausted” or “dysfunctional”) within the tumor microenvironment,...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Seo, Hyungseok, Chen, Joyce, González-Avalos, Edahí, Samaniego-Castruita, Daniela, Das, Arundhoti, Wang, Yueqiang H., López-Moyado, Isaac F., Georges, Romain O., Zhang, Wade, Onodera, Atsushi, Wu, Cheng-Jang, Lu, Li-Fan, Hogan, Patrick G., Bhandoola, Avinash, Rao, Anjana
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2019
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589758/
https://ncbi.nlm.nih.gov/pubmed/31152140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905675116
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