TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion

T cells expressing chimeric antigen receptors (CAR T cells) have shown impressive therapeutic efficacy against leukemias and lymphomas. However, they have not been as effective against solid tumors because they become hyporesponsive (“exhausted” or “dysfunctional”) within the tumor microenvironment,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Seo, Hyungseok, Chen, Joyce, González-Avalos, Edahí, Samaniego-Castruita, Daniela, Das, Arundhoti, Wang, Yueqiang H., López-Moyado, Isaac F., Georges, Romain O., Zhang, Wade, Onodera, Atsushi, Wu, Cheng-Jang, Lu, Li-Fan, Hogan, Patrick G., Bhandoola, Avinash, Rao, Anjana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2019
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589758/
https://ncbi.nlm.nih.gov/pubmed/31152140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905675116
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg