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Nr4a transcription factors limit CAR T cell function in solid tumors
T cells expressing chimeric antigen receptors (CAR) targeting human CD19 (huCD19) have exhibited impressive clinical efficacy against B cell malignancies(1,2). CAR-T cells have been less effective against solid tumors(3–5), in part because they enter a hyporesponsive (“exhausted” or “dysfunctional”)...
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| Izdano u: | Nature |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546093/ https://ncbi.nlm.nih.gov/pubmed/30814732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0985-x |
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