A carregar...
Nr4a transcription factors limit CAR T cell function in solid tumors
T cells expressing chimeric antigen receptors (CAR) targeting human CD19 (huCD19) have exhibited impressive clinical efficacy against B cell malignancies(1,2). CAR-T cells have been less effective against solid tumors(3–5), in part because they enter a hyporesponsive (“exhausted” or “dysfunctional”)...
Na minha lista:
| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546093/ https://ncbi.nlm.nih.gov/pubmed/30814732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0985-x |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|