TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion

Exhausted CD8(+) T cells (T(EX)) in chronic infections and cancer have limited effector function, high inhibitory receptor co-expression and extensive transcriptional changes compared to effector (T(EFF)) or memory (T(MEM)) CD8(+) T cells. T(EX) are important clinical targets of checkpoint blockade...

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Publicat a:Nature
Autors principals: Khan, Omar, Giles, Josephine R., McDonald, Sierra, Manne, Sasikanth, Ngiow, Shin Foong, Patel, Kunal P., Werner, Michael T., Huang, Alexander C., Alexander, Katherine A., Wu, Jennifer E., Attanasio, John, Yan, Patrick, George, Sangeeth M., Bengsch, Bertram, Staupe, Ryan P., Donahue, Greg, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Kaye, Jonathan, Berger, Shelley L., Wherry, E. John
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713202/
https://ncbi.nlm.nih.gov/pubmed/31207603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1325-x
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