TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion

Exhausted CD8(+) T cells (T(EX)) in chronic infections and cancer have limited effector function, high inhibitory receptor co-expression and extensive transcriptional changes compared to effector (T(EFF)) or memory (T(MEM)) CD8(+) T cells. T(EX) are important clinical targets of checkpoint blockade...

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Pubblicato in:Nature
Autori principali: Khan, Omar, Giles, Josephine R., McDonald, Sierra, Manne, Sasikanth, Ngiow, Shin Foong, Patel, Kunal P., Werner, Michael T., Huang, Alexander C., Alexander, Katherine A., Wu, Jennifer E., Attanasio, John, Yan, Patrick, George, Sangeeth M., Bengsch, Bertram, Staupe, Ryan P., Donahue, Greg, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Kaye, Jonathan, Berger, Shelley L., Wherry, E. John
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713202/
https://ncbi.nlm.nih.gov/pubmed/31207603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1325-x
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