TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion

Exhausted CD8(+) T cells (T(EX)) in chronic infections and cancer have limited effector function, high inhibitory receptor co-expression and extensive transcriptional changes compared to effector (T(EFF)) or memory (T(MEM)) CD8(+) T cells. T(EX) are important clinical targets of checkpoint blockade...

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Publicado no:Nature
Main Authors: Khan, Omar, Giles, Josephine R., McDonald, Sierra, Manne, Sasikanth, Ngiow, Shin Foong, Patel, Kunal P., Werner, Michael T., Huang, Alexander C., Alexander, Katherine A., Wu, Jennifer E., Attanasio, John, Yan, Patrick, George, Sangeeth M., Bengsch, Bertram, Staupe, Ryan P., Donahue, Greg, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Kaye, Jonathan, Berger, Shelley L., Wherry, E. John
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713202/
https://ncbi.nlm.nih.gov/pubmed/31207603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1325-x
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