Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

The transcription factors T-bet and Eomesodermin (Eomes) regulate CD8 T cell exhaustion through undefined mechanisms. Here, we show that the subcellular localization of T-bet and Eomes dictate their regulatory activity in exhausted T cells (T(EX)s). T(EX)s had a higher ratio of nuclear Eomes:T-bet t...

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Udgivet i:Cell Rep
Main Authors: McLane, Laura M., Ngiow, Shin Foong, Chen, Zeyu, Attanasio, John, Manne, Sasikanth, Ruthel, Gordon, Wu, Jennifer E., Staupe, Ryan P., Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Freedman, Bruce D., Betts, Michael R., Wherry, E. John
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195461/
https://ncbi.nlm.nih.gov/pubmed/33979613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109120
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