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Unique transmembrane domain interactions differentially modulate integrin αvβ3 and αIIbβ3 function

Lateral transmembrane (TM) helix–helix interactions between single-span membrane proteins play an important role in the assembly and signaling of many cell-surface receptors. Often, these helices contain two highly conserved yet distinct interaction motifs, arranged such that the motifs cannot be en...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Litvinov, Rustem I., Mravic, Marco, Zhu, Hua, Weisel, John W., DeGrado, William F., Bennett, Joel S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589676/
https://ncbi.nlm.nih.gov/pubmed/31160446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904867116
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