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Multi-Step Fibrinogen Binding to the Integrin αIIbβ3 Detected Using Force Spectroscopy

The regulated ability of integrin αIIbβ3 to bind fibrinogen plays a crucial role in platelet aggregation and hemostasis. We have developed a model system based on laser tweezers, enabling us to measure specific rupture forces needed to separate single receptor-ligand complexes. First of all, we perf...

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Bibliografische gegevens
Hoofdauteurs: Litvinov, Rustem I., Bennett, Joel S., Weisel, John W., Shuman, Henry
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Biophysical Society 2005
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366781/
https://ncbi.nlm.nih.gov/pubmed/16040750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.061887
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