Resolving Two-dimensional Kinetics of the Integrin αIIbβ3-Fibrinogen Interactions Using Binding-Unbinding Correlation Spectroscopy

Using a combined experimental and theoretical approach named binding-unbinding correlation spectroscopy (BUCS), we describe the two-dimensional kinetics of interactions between fibrinogen and the integrin αIIbβ3, the ligand-receptor pair essential for platelet function during hemostasis and thrombos...

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Bibliografiske detaljer
Main Authors: Litvinov, Rustem I., Mekler, Andrey, Shuman, Henry, Bennett, Joel S., Barsegov, Valeri, Weisel, John W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471694/
https://ncbi.nlm.nih.gov/pubmed/22893701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404848
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