Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

BACKGROUND: Type I interferons (IFN-I) have recently emerged as key regulators of tumor response to chemotherapy and immunotherapy. However, IFN-I function in cytotoxic T lymphocytes (CTLs) in the tumor microenvironment is largely unknown. METHODS: Tumor tissues and CTLs of human colorectal cancer p...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Lu, Chunwan, Klement, John D., Ibrahim, Mohammed L., Xiao, Wei, Redd, Priscilla S., Nayak-Kapoor, Asha, Zhou, Gang, Liu, Kebin
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589175/
https://ncbi.nlm.nih.gov/pubmed/31228946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0635-8
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